The American-born actor told the Hong Kong media recently that Selesner, who is in her 30s, blames herself for their childless state.
Said Wu, who turns 37 next month, and is often overseas for work: "We don't have a lot of time together, so how can she get pregnant? I'll comfort her whenever I can and tell her it's not her fault...
"Both of us are over 36 and our biological clocks are ticking. I don't want to miss the opportunity to kick a ball around with my son."
Model and Channel VJ Selesner added: "Daniel is very sweet. His family has never pressured us to have children. The pressure is all from himself because he wants to make his parents happy.
"I know it's hard for us to have a baby when we are in different countries. If we can't conceive naturally, we will try artificial insemination."
The couple, who vacationed in Phuket late last month, married in South Africa in April 2010 after dating for eight years.
In an interview with The New Paper one month after their nuptials, Selesner had said Wu is the first guy in her life she was willing to get pregnant for and that "this says a lot for me".
Wu also told the Hong Kong media in July last year that they were about to begin planning for a child.
Now, more than a year later, they are still trying.
Wu is an only son, and his elderly father longs for a grandson to continue the family name.
Wu, whose latest movie Overheard 2 opens here next Thursday, said he is ready to cut back on his work to spend more time with Selesner.
"I recently became a CEO (of a movie company) and I feel becoming a father is harder than being a good manager," he said.
"(Fatherhood) is like winning the lottery. So once I finish filming the Chinese movie The Last Supper in China, I will concentrate on spending time with Lisa and not work overseas for long periods of time."
He added that they may seek medical help if a baby still doesn't come after another year of trying.
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